Morphological and biochemical changes in the liver of various species in experimental phospholipidosis after diethylaminoethoxyhexestrol treatment
Identifieur interne : 003A17 ( Main/Exploration ); précédent : 003A16; suivant : 003A18Morphological and biochemical changes in the liver of various species in experimental phospholipidosis after diethylaminoethoxyhexestrol treatment
Auteurs : Felix A. De La Iglesia [Canada] ; George Feuer [Canada] ; Edward J. Mcguire [Canada] ; Akira Takada [Canada, Japon]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1975.
English descriptors
- Teeft :
- Abnormal phospholipids, Acid phosphatase, Acid phosphatase activity, Adachi, Adenosine triphosphatase, Autophagic vacuoles, Bile canaliculi, Biochemical changes, Canaliculus, Cell organelle fractions, Cell organelles, Control livers, Cytidine monophosphatase, Dela iglesia, Dense bodies, Diethylaminoethoxyhexestrol, Differential interference contrast microscopy, Diphosphatase, Droplet, Drug action, Drug effects, Drug treatment, Electron microscopy, Endoplasmic, Endoplasmic reticulum, Endoplasmic reticulum cisternae, Enzyme activities, Enzyme activity, Experimental phospholipidosis, Fatty liver, Feuer, Golgi, Golgi apparatus, Guinea, Guinea pigs, Hamster, Hamster liver, Hepatocyte cytoplasm, Hepatocytes, Histochemical studies, Iglesia, Individual phospholipids, Inosine diphosphatase, Kupffer, Kupffer cells, Lamellar bodies, Lamellated bodies, Light microscopy, Lipid, Liver, Liver homogenates, Liver lobule, Liver lysosomes, Lysosomal, Lysosome, Methyl transferase, Methyl transferase activity, Microscopy, Microsomal, Microsomal phospholipids, Mouse liver, Myeloid, Myeloid bodies, Novikoff, Organelle, Other organs, Outer membrane, Phosphatase, Phosphatidic acid, Phospholipid, Phospholipid content, Phospholipid histochemistry, Phospholipid metabolism, Phospholipidosis, Protein content, Relative distribution, Reticulum, Secondary lysosomes, Small membrane whorls, Small myeloid bodies, Supernatant fraction, Thiamine pyrophosphatase, Unidentified phospholipids, Various species, Wide range, Yamamoto.
Abstract
Abstract: The mechanism of druginduced experimental phospholipidosis was studied in several species by the administration of diethylaminoethoxyhexestrol. Rabbits, rats, mice, dogs, and guinea pigs developed microscopic and biochemical abnormalities, while hamsters were less affected. In the liver of affected species characteristic subcellular changes were found, accompanied by phospholipid accumulation. Hepatic lesions consisted of concentric lamellar bodies with varying degrees of osmic affinity, representing secondary lysosomes characterized by cytochemical methods. Accumulation of these bodies was also seen in Kupffer, endothelial, and biliary epithelial cells. The intensity of the changes was related to species susceptibility. Biochemical studies revealed an overall increase of total phospholipids in the affected species, together with changes in the relative distribution of individual phospholipids and the appearance of unidentified components. The activity of microsomal drug metabolizing enzymes and microsomal phospholipid synthesis were diminished. The lesions closely resembled those observed in man after treatment with diethylaminoethoxyhexestrol and are related to altered phospholipid metabolism with subsequent changes in microsomal drug metabolizing enzyme activity.
Url:
DOI: 10.1016/0041-008X(75)90172-6
Affiliations:
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Mcguire</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Warner-Lambert Research Institute, Sheridan Park, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Biochemistry, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Takada, Akira" sort="Takada, Akira" uniqKey="Takada A" first="Akira" last="Takada">Akira Takada</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Warner-Lambert Research Institute, Sheridan Park, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Biochemistry, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>1 Present address: Department of Internal Medicine, Kanazawa Medical University, Uchinada</wicri:regionArea><wicri:noRegion>Uchinada</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">34</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="28">28</biblScope><biblScope unit="page" to="44">44</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormal phospholipids</term><term>Acid phosphatase</term><term>Acid phosphatase activity</term><term>Adachi</term><term>Adenosine triphosphatase</term><term>Autophagic vacuoles</term><term>Bile canaliculi</term><term>Biochemical changes</term><term>Canaliculus</term><term>Cell organelle fractions</term><term>Cell organelles</term><term>Control livers</term><term>Cytidine monophosphatase</term><term>Dela iglesia</term><term>Dense bodies</term><term>Diethylaminoethoxyhexestrol</term><term>Differential interference contrast microscopy</term><term>Diphosphatase</term><term>Droplet</term><term>Drug action</term><term>Drug effects</term><term>Drug treatment</term><term>Electron microscopy</term><term>Endoplasmic</term><term>Endoplasmic reticulum</term><term>Endoplasmic reticulum cisternae</term><term>Enzyme activities</term><term>Enzyme activity</term><term>Experimental phospholipidosis</term><term>Fatty liver</term><term>Feuer</term><term>Golgi</term><term>Golgi apparatus</term><term>Guinea</term><term>Guinea pigs</term><term>Hamster</term><term>Hamster liver</term><term>Hepatocyte cytoplasm</term><term>Hepatocytes</term><term>Histochemical studies</term><term>Iglesia</term><term>Individual phospholipids</term><term>Inosine diphosphatase</term><term>Kupffer</term><term>Kupffer cells</term><term>Lamellar bodies</term><term>Lamellated bodies</term><term>Light microscopy</term><term>Lipid</term><term>Liver</term><term>Liver homogenates</term><term>Liver lobule</term><term>Liver lysosomes</term><term>Lysosomal</term><term>Lysosome</term><term>Methyl transferase</term><term>Methyl transferase activity</term><term>Microscopy</term><term>Microsomal</term><term>Microsomal phospholipids</term><term>Mouse liver</term><term>Myeloid</term><term>Myeloid bodies</term><term>Novikoff</term><term>Organelle</term><term>Other organs</term><term>Outer membrane</term><term>Phosphatase</term><term>Phosphatidic acid</term><term>Phospholipid</term><term>Phospholipid content</term><term>Phospholipid histochemistry</term><term>Phospholipid metabolism</term><term>Phospholipidosis</term><term>Protein content</term><term>Relative distribution</term><term>Reticulum</term><term>Secondary lysosomes</term><term>Small membrane whorls</term><term>Small myeloid bodies</term><term>Supernatant fraction</term><term>Thiamine pyrophosphatase</term><term>Unidentified phospholipids</term><term>Various species</term><term>Wide range</term><term>Yamamoto</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The mechanism of druginduced experimental phospholipidosis was studied in several species by the administration of diethylaminoethoxyhexestrol. Rabbits, rats, mice, dogs, and guinea pigs developed microscopic and biochemical abnormalities, while hamsters were less affected. In the liver of affected species characteristic subcellular changes were found, accompanied by phospholipid accumulation. Hepatic lesions consisted of concentric lamellar bodies with varying degrees of osmic affinity, representing secondary lysosomes characterized by cytochemical methods. Accumulation of these bodies was also seen in Kupffer, endothelial, and biliary epithelial cells. The intensity of the changes was related to species susceptibility. Biochemical studies revealed an overall increase of total phospholipids in the affected species, together with changes in the relative distribution of individual phospholipids and the appearance of unidentified components. The activity of microsomal drug metabolizing enzymes and microsomal phospholipid synthesis were diminished. The lesions closely resembled those observed in man after treatment with diethylaminoethoxyhexestrol and are related to altered phospholipid metabolism with subsequent changes in microsomal drug metabolizing enzyme activity.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Japon</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="De La Iglesia, Felix A" sort="De La Iglesia, Felix A" uniqKey="De La Iglesia F" first="Felix A." last="De La Iglesia">Felix A. De La Iglesia</name></noRegion><name sortKey="De La Iglesia, Felix A" sort="De La Iglesia, Felix A" uniqKey="De La Iglesia F" first="Felix A." last="De La Iglesia">Felix A. De La Iglesia</name><name sortKey="Feuer, George" sort="Feuer, George" uniqKey="Feuer G" first="George" last="Feuer">George Feuer</name><name sortKey="Feuer, George" sort="Feuer, George" uniqKey="Feuer G" first="George" last="Feuer">George Feuer</name><name sortKey="Mcguire, Edward J" sort="Mcguire, Edward J" uniqKey="Mcguire E" first="Edward J." last="Mcguire">Edward J. Mcguire</name><name sortKey="Mcguire, Edward J" sort="Mcguire, Edward J" uniqKey="Mcguire E" first="Edward J." last="Mcguire">Edward J. Mcguire</name><name sortKey="Takada, Akira" sort="Takada, Akira" uniqKey="Takada A" first="Akira" last="Takada">Akira Takada</name><name sortKey="Takada, Akira" sort="Takada, Akira" uniqKey="Takada A" first="Akira" last="Takada">Akira Takada</name></country><country name="Japon"><noRegion><name sortKey="Takada, Akira" sort="Takada, Akira" uniqKey="Takada A" first="Akira" last="Takada">Akira Takada</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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